PXD064985-1

PXD064985 is an original dataset announced via ProteomeXchange.

Title	Cellular and molecular effects of iron-based pigments on macrophages
Description	Tattoos are becoming increasingly popular across generations, with 10-20% of the population in Europe and the United States bearing at least one tattoo. Tattoos represent an intradermal injection of pigments (i.e. coloured insoluble micro- and nano-particles), which remain in place throughout life. Although tattoos have existed for centuries, the question of their health impact has really arisen rather lately, so that a significant gap in our understanding of the cellular and molecular long-term effects of these pigments on the body remains. In this project, we investigate a wide range of tattoo pigments on macrophages. Macrophages, pivotal in pigment persistence through phagocytic processes and capture-release-recapture cycles, are also key players in the inflammatory response and tissue homeostasis. Dysregulation in macrophage functionalities can potentially lead to substantial health consequences such as deficient immune response or such as sarcoidosis. To assess the long-term effects of tattoos, we tested iron-based pigments (which are widely used in the medical field for dermopigmentation of the nipple-areola complex after mastectomy) using an exposure scheme consisting in an acute exposure for 24 hours and a 5-days post exposure recovery period. Proteomic analyses were conducted to understand the underlying cellular mechanisms.
HostingRepository	PRIDE
AnnounceDate	2025-10-09
AnnouncementXML	Submission_2025-10-09_01:27:55.169.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD064985
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Hélène Diemer
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-13 02:28:08	ID requested
⏵ 1	2025-10-09 01:27:55	announced

10.6019/PXD064985;

10.1016/J.IMPACT.2025.100578;

submitter keyword: Macrophage,Mouse, tatoo pigments, LC-MS/MS

Christine Carapito
contact affiliation	Laboratoire de Spectrometrie de Masse BioOrganique (LSMBO), Universite de Strasbourg, CNRS, IPHC UMR 7178, 67087 Strasbourg, France
contact email	ccarapito@unistra.fr
lab head
Hélène Diemer
contact affiliation	LSMBO
contact email	hdiemer@unistra.fr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD064985
     1. Label: PRIDE project
     2. Name: Cellular and molecular effects of iron-based pigments on macrophages