PXD064951 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | HLA-DRB1 allelic combinations differentially shape dendritic cell antigen presentation enhanced by tumor cell line lysate-pulsing |
| Description | The study explores the anti-tumor immune response through the analysis of the HLA-II immunopeptidome of dendritic cells (DCs) from HLA-heterozygous donors pulsed with a protein extract from the MCF-7 tumor cell line. The objective was to characterize how different HLA-DRB1 allele combinations influence peptide presentation and how DC pulsing affects the immunopeptidome profile. Our findings demonstrate that HLA-DR heterozygosity significantly shapes the peptide repertoire in an allele-specific manner, with allele dominance modulated by specific allelic combinations. Notably, tumor-derived peptides such as annexin A2, galectin-1, and elongation factor 1-alpha 2 were identified in association with particular HLA-DRB1 alleles. These insights provide valuable information for the design of personalized immunotherapies based on peptide-pulsed DCs aimed at enhancing CD4+ tumor-infiltrating lymphocyte responses. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-09 |
| AnnouncementXML | Submission_2026-02-08_16:19:59.923.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Gonzalo Lázaro |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 240 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-06-12 11:43:54 | ID requested | |
| ⏵ 1 | 2026-02-08 16:20:00 | announced | |
Publication List
| L, á, zaro G, Cedano JA, Faus M, Roura-Mir C, Garrig, ó, s L, P, é, rez-Garc, í, a J, Rom, á, n-Garc, í, a J, Cort, é, s J, Aran A, Mart, í M, HLA-DRB1 Allelic Combinations Differentially Shape Dendritic Cell Antigen Presentation Enhanced by Tumour Cell Line Lysate-Pulsing. HLA, 107(2):e70563(2026) [pubmed] |
| 10.1111/tan.70563; |
Keyword List
| submitter keyword: T cell, heterozygosity, mass spectrometry, peptide, dendritic cell,HLA-DRB1 |
Contact List
| Mercè Martí |
|---|
| contact affiliation | Immunology Unit, Department of Cell Biology, Physiology and Immunology, Institut de Biotecnologia i Biomedicina (IBB), Universitat Autònoma de Barcelona (UAB), Bellaterra (Cerdanyola del Vallès), Spain Biosensing and Bioanalysis Group, Institut de Biotecnologia i Biomedicina (IBB), Universitat Autònoma de Barcelona (UAB), Bellaterra (Cerdanyola del Vallès), Spain |
| contact email | Merce.Marti@uab.cat |
| lab head | |
| Gonzalo Lázaro |
|---|
| contact affiliation | Universitat Autónoma de Barcelona |
| contact email | gonzalo.lazaro@uab.cat |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD064951 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD064951
- Label: PRIDE project
- Name: HLA-DRB1 allelic combinations differentially shape dendritic cell antigen presentation enhanced by tumor cell line lysate-pulsing
