PXD064940-1

PXD064940 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Human HRI Autophosphorylation Profile
Description	Heme-regulated inhibitorRegulated Inhibitor (HRI) is one of the four mammalian kinases that phosphorylate eIF2α, facilitating a cellular response to stress through the regulation of mRNA translation. Originally identified as a heme sensor in erythroid progenitor cells, HRI has since emerged as a potential therapeutic target in both cancer and neurodegeneration. Here we purified recombinant expressed human HRI and allowed it to autophosphorylate.
HostingRepository	PRIDE
AnnounceDate	2025-06-18
AnnouncementXML	Submission_2025-06-18_01:19:09.728.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD064940
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Glenn Masson
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	dihydroxylated residue; phosphorylated residue; acetylated residue; monohydroxylated residue; deamidated residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-12 07:20:46	ID requested
⏵ 1	2025-06-18 01:19:10	announced

Publication List

Kanta S, Vinciauskaite V, Neill G, Muqit MMK, Masson GR, Structural insights into allosteric inhibition of HRI kinase by heme binding via HDX-MS. Biochem J, 482(12):(2025) [pubmed]
10.1042/bcj20253072;
10.6019/PXD064940;

Kanta S, Vinciauskaite V, Neill G, Muqit MMK, Masson GR, Structural insights into allosteric inhibition of HRI kinase by heme binding via HDX-MS. Biochem J, 482(12):(2025) [pubmed]

10.1042/bcj20253072;

10.6019/PXD064940;

Keyword List

submitter keyword: Autophosphorylation,HRI, Kinase

submitter keyword: Autophosphorylation,HRI, Kinase

Contact List

Glenn Masson
contact affiliation	School of Medicine, University of Dundee, Dundee
contact email	gmasson001@dundee.ac.uk
lab head
Glenn Masson
contact affiliation	University of Dundee
contact email	gmasson001@dundee.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD064940
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD064940

PRIDE project URI

Repository Record List

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