PXD064919-1

PXD064919 is an original dataset announced via ProteomeXchange.

Title	Systemic effects of pesticides on insectivorous bats: a proteomics approach
Description	Bats play a critical role in controlling agricultural pests, yet foraging in croplands exposes them to hazardous pesticides. These chemicals pose significant risks for bats by impairing immune function, locomotion, and cognition even at low doses, jeopardizing their survival and ecological role. Here, we employed proteomics—a powerful, yet underused, tool in ecotoxicology—to examine the systemic effects of Chlorpyrifos (CPF), a commonly used insecticide, on big brown bats (Eptesicus fuscus). We exposed bats through their diet to an environmentally relevant concentration of CPF for three or seven consecutive days and took plasma samples before and after exposure for non-targeted proteomics. We identified over 100 proteins with significant abundance changes before and after exposure to the pesticide. Exposure to CPF altered a wide range of molecular processes including cell communication, cell metabolism, and DNA maintenance. Remarkably, we found changes in key proteins involved in immune response, T cell activation, and inflammation. These effects could reduce a bat’s immune response, increasing their susceptibility to viral infections, and intensifying the risk of shedding and transmitting pathogens to other species. Our results provide new insights into the toxicity of pesticides and highlight the utility of proteomics for assessing toxicant effects in understudied and vulnerable species like bats. Considering a One Health approach and the role of bats as reservoirs for numerous zoonotic pathogens, our work has broad implications for bat and human health.
HostingRepository	PanoramaPublic
AnnounceDate	2026-04-29
AnnouncementXML	Submission_2026-04-29_16:37:05.317.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Denina Simmons
SpeciesList	scientific name: Eptesicus fuscus; NCBI TaxID: 29078;
ModificationList	Phospho; Carbamyl; Carbamidomethyl; Oxidation
Instrument	6545 Q-TOF LC/MS

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-12 00:56:04	ID requested
⏵ 1	2026-04-29 16:37:06	announced

Sandoval-Herrera N, Lara-Jacobo L, Faure PA, Simmons D, Welch K, Systemic Effects of Pesticides on Insectivorous Bats: A Proteomics Approach. Integr Comp Biol, 65(6):1810-1825(2025) [pubmed]

submitter keyword: Chlorpyrifos, eco-immunology, ecotoxicology, Chiroptera, toxicogenomics

Denina Simmons
contact affiliation	Ontario Tech University
contact email	denina.simmons@ontariotechu.ca
lab head
Denina Simmons
contact affiliation	Ontario Tech University
contact email	denina.simmons@ontariotechu.ca
dataset submitter

Panorama Public dataset URI