⮝ Full datasets listing
PXD064798-1
PXD064798 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | METTL5 blockade enhances anti-tumor immune response via inducing neoantigen generation |
| Description | We demonstrate that inhibition of rRNA methyltransferase METTL5 increases neoantigen production and enhances anti-tumor immunity. Mechanistically, METTL5-mediated m6A modification located at the decoding center of small ribosomal subunit maintains the proper conformation of ribosome during mRNA translation. METTL5 depletion leads to abnormal ribosome function, decreased translation fidelity, increased production of tumor cell-specific antigens derived from non-canonical translation, and subsequently induces an anti-tumor immune response. |
| HostingRepository | iProX |
| AnnounceDate | 2025-07-25 |
| AnnouncementXML | Submission_2026-07-29_18:01:29.855.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hao Chen |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Thermo Fisher Scientific instrument model |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-06-09 19:00:54 | ID requested | |
| ⏵ 1 | 2026-07-29 18:01:30 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Tumor immunity, Neoantigen |
Contact List
| Hao Chen | |
|---|---|
| contact affiliation | Southern University of Science and Technology |
| contact email | chenh7@sustech.edu.cn |
| lab head | |
| Hao Chen | |
| contact affiliation | Southern University of Science and Technology |
| contact email | chenh7@sustech.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
