PXD064672 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A human-specific long noncoding RNA regulator of antigen-presenting cell viability and antimicrobial defense |
| Description | Macrophages are essential for balancing pathogen clearance with tissue homeostasis, yet the molecular regulators of this equilibrium remain incompletely defined. Here, we identify LINC01857, a primate-specific long intergenic noncoding RNA (lincRNA), as a critical modulator of macrophage survival and antimicrobial defense. LINC01857 is induced during monocyte-to-macrophage differentiation, but rapidly downregulated upon bacterial challenge in an NFκB-dependent manner. Under homeostatic conditions, this lincRNA dampens the expression of adhesion, phagocytosis and invasion factors, including SIGLEC1 and MMP7, and suppresses apoptosis. Depletion of LINC01857 during infection with Salmonella Typhimurium limits intracellular bacterial replication, creating a dead-end niche for the pathogen. Conversely, enforced LINC01857 expression promotes pathogen propagation. Mechanistically, LINC01857 interacts with the adaptor protein 14-3-3β to support macrophage survival. Notably, downregulation of LINC01857 is mirrored in circulating immune cells from patients with severe COVID-19 and sepsis. Together, our findings position LINC01857 as a central regulator linking macrophage survival to host-pathogen interaction and disease pathophysiology. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-02 |
| AnnouncementXML | Submission_2026-07-02_08:47:16.414.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD064672 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Uwe Linne |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-06-05 03:24:52 | ID requested | |
| ⏵ 1 | 2026-07-02 08:47:16 | announced | |
Publication List
Keyword List
| submitter keyword: macrophage,lncRNA, immunity, 14-3-3, Salmonella |
Contact List
| Dr. Uwe Linne |
|---|
| contact affiliation | Philipps University Marburg Faculty of Chemistry Core Facility for Mass Spectrometry Hans-Meerwein Str. 4 35032 Marburg GERMANY |
| contact email | linneu@staff.uni-marburg.de |
| lab head | |
| Uwe Linne |
|---|
| contact affiliation | Head of Core Facility Mass Spectrometry, Faculty of Chemistry, Philipps-University Marburg |
| contact email | linneu@staff.uni-marburg.de |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD064672 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD064672
- Label: PRIDE project
- Name: A human-specific long noncoding RNA regulator of antigen-presenting cell viability and antimicrobial defense
