PXD064655-1

PXD064655 is an original dataset announced via ProteomeXchange.

Title	Thermal Liquid Biopsy for Early Colorectal Cancer Diagnosis integrating mass spectrometry proteomic biomarker discovery
Description	Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. When detected early, mortality rates can be significantly reduced, as surgical intervention in early stages often leads to curative outcomes. However, current biomarkers, such as carcinoembryonic antigen (CEA), have limitations in diagnostic accuracy, highlighting the need for improved methodologies. This study included 328 Danish patients with CRC and 355 symptomatic patients with non-organ-specific signs of cancer, but with negative clinical and computed tomography evaluations. Thermal Liquid Biopsy (TLB) thermograms were analyzed to assess partial excess heat capacity of serum solutions relative to a reference buffer solution, as a function of temperature. Here, we demonstrate the potential of combining clinical biomarkers with global thermogram-based information from TLB to enhance early CRC diagnosis. Furthermore, the integration of TLB with proteomic analysis enables the identification of novel biomarkers, offering new insights into CRC prognosis and disease characterization.
HostingRepository	PRIDE
AnnounceDate	2026-01-12
AnnouncementXML	Submission_2026-01-11_16:49:31.196.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Matthew McKay
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-04 22:36:12	ID requested
⏵ 1	2026-01-11 16:49:31	announced

Dataset with its publication pending

submitter keyword: biomarkers

classification model

colorectal cancer (CRC)

diagnosis

machine learning algorithms

mass spectrometry (MS)

prognosis

thermal liquid biopsy (TLB)

Olga Abian
contact affiliation	Universidad de Zaragoza-IIS Aragon, 50009 Zaragoza, Spain.
contact email	oabifra@unizar.es
lab head
Matthew McKay
contact affiliation	University of Sydney
contact email	matthew.mckay@sydney.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD064655

PRIDE project URI

• PRIDE
  1. PXD064655
     1. Label: PRIDE project
     2. Name: Thermal Liquid Biopsy for Early Colorectal Cancer Diagnosis integrating mass spectrometry proteomic biomarker discovery