PXD064620-2

PXD064620 is an original dataset announced via ProteomeXchange.

Title	Tmem117, an oligodendrocyte-enriched regulator of NCX activity, links central nervous system myelin homeostasis to counterregulation and metabolic health.
Description	The influence of metabolic dysfunction on myelin has been well documented, yet whether central nervous system myelin homeostasis contributes to systemic metabolic regulation remains unclear. Here we identify Tmem117, a previously uncharacterized oligodendrocyte-enriched protein, as a critical regulator of this axis. Conditional deletion of Tmem117 in mature oligodendrocytes induces ER stress, broad proteome dysregulation, and demyelination, with myelin disruption leading to sex-specific effects on counterregulatory response, glucose tolerance, and hepatic lipid accumulation. Mechanistically, we provide evidence that Tmem117 modulates the sodium-calcium exchanger NCX1. These findings uncover a reciprocal link between central nervous system myelin integrity and systemic metabolic homeostasis, and position Tmem117 as a potential target for cell-specific modulation of NCX activity.
HostingRepository	PRIDE
AnnounceDate	2026-08-13
AnnouncementXML	Submission_2026-08-13_04:05:48.692.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sevasti Gaspari
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-04 05:08:57	ID requested
1	2026-08-07 04:48:01	announced
⏵ 2	2026-08-13 04:05:49	announced	2026-08-13: Updated project metadata.

10.1073/pnas.2530122123;

submitter keyword: brain, myelin, mouse,Tmem117, oligodendrocytes

Sevasti Gaspari
contact affiliation	Institute of Pharmacology and Toxicology, University of Zurich, CH-8057 Zurich, Switzerland.
contact email	sevasti.gaspari@pharma.uzh.ch
lab head
Sevasti Gaspari
contact affiliation	Institute of Pharmacology and Toxicology, University of Zurich
contact email	sevasti.gaspari@pharma.uzh.ch
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD064620
     1. Label: PRIDE project
     2. Name: Tmem117, an oligodendrocyte-enriched regulator of NCX activity, links central nervous system myelin homeostasis to counterregulation and metabolic health.