PXD064580 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Cutaneous Lupus Erythematosus: proteomics salivary profiling |
| Description | Background: Cutaneous lupus erythematosus (CLE) is a complex autoimmune condition with limited data on its molecular underpinnings. Saliva, as plasma filtrate fluid may be a promising tool for biomarkers discovery, since it is an easily accessible biofluid. This study aimed to characterize the salivary proteomic profile of CLE patients compared to healthy controls, to identify potential disease-specific biomarkers. Methods: Ten females diagnosed with CLE and twelve controls without autoimmune conditions were included in the study. Saliva samples were collected under controlled conditions and analyzed using mass spectrometry and chromatography. Proteomic analysis was performed with the nanoElute nanoflow system coupled to a timsTof-Pro mass spectrometer. Results: Among the 104 proteins identified, six showed statistically significant differences between groups. PEBP1 (RKIP), ARG1, TALDO, and CTSZ were upregulated in CLE, while TFF3 and PRDX4 were absent. These proteins are involved in immune regulation, metabolic processes, redox balance, and inflammation. RKIP and ARG1 showed high discriminatory power (AUROC = 1.0), suggesting their potential as CLE biomarkers. Conclusion: This study establishes a distinct salivary proteomic signature in CLE, highlighting a panel of proteins with diagnostic potential. The use of saliva and proteomic techniques offers a powerful approach to unravel CLE pathophysiology and supports future research on non-invasive biomarkers for disease monitoring and personalized care. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-22 |
| AnnouncementXML | Submission_2025-12-21_17:07:07.961.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Giovanna Florezi |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-06-03 16:18:31 | ID requested | |
| ⏵ 1 | 2025-12-21 17:07:09 | announced | |
Publication List
| Florezi GP, Barone FP, Labate MTV, Labate CA, Nico MMS, Louren, ç, o SV, Salivary proteomics profiling in cutaneous lupus erythematosus. Lupus, 35(2):120-128(2026) [pubmed] |
| 10.1177/09612033251407232; |
Keyword List
| submitter keyword: cutaneous lupus erythematosus, proteomics, saliva |
Contact List
| Carlos Alberto Labate |
|---|
| contact affiliation | Escola Superior de Agricultura Luiz de Queiroz da Universidade de São Paulo |
| contact email | calabate@usp.br |
| lab head | |
| Giovanna Florezi |
|---|
| contact affiliation | Faculdade de Odontologia da Universidade de São Paulo |
| contact email | giovanna.florezi@usp.br |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD064580
- Label: PRIDE project
- Name: Cutaneous Lupus Erythematosus: proteomics salivary profiling
