PXD064499 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Pro-regenerative fingerprints identified in a sub-population of adult mouse cardiomyocytes by integrative single-cell proteomics-Pilot dataset |
| Description | We present a new experimental and computational workflow to analyze single-cell proteomics data applied to single-cardiomyocytes. By using an optimized isolation procedure and by taking advantage of the integrative capabilities of iSanXoT application, we eliminate batch effects, minimize cell size-related biases, obtain quantitative subcellular compartment information and detect protein alterations within subcellular compartments. This approach enhances data quantification accuracy and facilitates biological interpretation. We show that the overexpression of the Myc transcription factor switches the metabolism of adult cardiomyocytes and establishes a subpopulation of pro-regenerative cardiomyocytes. The reported advances validate the used workflow for the systematyic analysis of single-cell proteomics data and shows its application in defining subpopulations of cells that may be prompt to regenerate based on their proteomic signature. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-06 |
| AnnouncementXML | Submission_2026-04-06_02:25:08.147.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD064499 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Consuelo Marín-Vicente |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | TMT6plex-126 reporter+balance reagent acylated residue |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-06-02 01:08:46 | ID requested | |
| ⏵ 1 | 2026-04-06 02:25:08 | announced | |
Publication List
Keyword List
Contact List
| Jesús Vázquez |
|---|
| contact affiliation | Cardiovascular Proteomics group, Spanish National Center for Cardiovascular Research, Madrid, Spain |
| contact email | jesus.vazquez@cnic.es |
| lab head | |
| Consuelo Marín-Vicente |
|---|
| contact affiliation | Spanish National Center for Cardiovascular Research (CNIC) |
| contact email | cmarin@cnic.es |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD064499 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD064499
- Label: PRIDE project
- Name: Pro-regenerative fingerprints identified in a sub-population of adult mouse cardiomyocytes by integrative single-cell proteomics-Pilot dataset
