⮝ Full datasets listing
PXD064462-1
PXD064462 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Radulovic_2025_Response dynamics of discrete subiculum-retrosplenial cortex projections underlying trace fear conditioning |
| Description | Associating temporally discontinuous events is one of the key characters of episodic memory. In trace fear conditioning (TFC), the CA1-subiculum (SUB) complex is required for tone-shock associations over a temporal trace, while the retrosplenial cortex (RSP) serves as a hub for temporal coding. How these regions interact during TFC remains unclear. Here, we show that molecularly distinct VGluT1 and VGluT2 SUB to RSP projections redundantly contribute to the associative component of TFC, whereas VGluT2 SUB to RSP projections selectively processes the temporal component. In these projections, trace memory formation was associated with increased and decreased bulk calcium activity at tone and trace onset, respectively, an activity pattern that was reestablished during memory recall. Such pattern was not observed in CA subfields, suggesting that associations and temporal gaps of TFC are integrated at the SUB before being presented to the RSP. Our findings establish a circuit mechanism for representing complex temporal information in episodic memory. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-01-05 |
| AnnouncementXML | Submission_2026-01-05_08:19:31.954.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Jeffrey N. Savas |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | unknown modification |
| Instrument | Orbitrap Ascend |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-05-30 14:14:33 | ID requested | |
| ⏵ 1 | 2026-01-05 08:19:32 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: trace fear conditioning, CA1-subiculum, retrosplenial cortex, VGluT1 and VGluT2, DatasetType:Proteomics |
Contact List
| jeffrey Savas | |
|---|---|
| contact affiliation | Northwestern University Feinberg |
| contact email | jeffrey.savas@northwestern.edu |
| lab head | |
| Jeffrey N. Savas | |
| contact affiliation | Northwestern University |
| contact email | jeffrey.savas@northwestern.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v10/MSV000098056/ |
