PXD064439-1

PXD064439 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling reveals potential plasmatic biomarkers for pancreatic adenocarcinoma in Brazilian patients
Description	Pancreatic cancer is one of the most lethal cancer types worldwide, with the majority of the diagnostics being pancreatic adenocarcinomas (PDAC). Early and accurate diagnosis are among the best alternatives to improve treatment effectiveness and survival of PDCA patients; however, plasmatic biomarkers molecules are scarce. Here, we describe a proteomic screening on depleted plasma from 29 PDAC patients and 30 healthy controls, aiming to identify potential biomarkers for PDAC diagnosis. We observed 121 differentially expressed proteins (DEPs), which were associated with the tumor biology and clinical behavior. We emphasize the potential of three over-expressed proteins (ORM1, ORM2, and SERPINA1), and four down-expressed proteins (ALDOA, PPIA, VCL, and SPARC) as biomarkers in PDAC, which were also correlated with disease staging. It was also demonstrated that some proteins could be used as complementary biomarkers associated with gold-standard CA19-9. Our high throughput proteomics approach suggests a set of proteins with potential use in PDAC diagnosis, giving light to future validation and application in clinical practice, enabling target proteomics and other serological assays.
HostingRepository	PRIDE
AnnounceDate	2025-10-24
AnnouncementXML	Submission_2025-10-24_07:40:55.977.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michel Batista
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-30 02:06:15	ID requested
⏵ 1	2025-10-24 07:40:56	announced

Dataset with its publication pending

submitter keyword: Human, Pancreatic cancer, Plasma, Proteomics, LC-MS/MS

Mateus Nóbrega Aoki
contact affiliation	Laboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Curitiba, Brazil
contact email	mateus.aoki@fiocruz.br
lab head
Michel Batista
contact affiliation	Fiocruz
contact email	batista.mic@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD064439
     1. Label: PRIDE project
     2. Name: Proteomic profiling reveals potential plasmatic biomarkers for pancreatic adenocarcinoma in Brazilian patients