PXD064371-1

PXD064371 is an original dataset announced via ProteomeXchange.

Title	Multiple reaction monitoring assay for differentiating gastric cancer from acid peptic diseases
Description	Gastric cancers (GCs) are often diagnosed in advanced stages, owing to non-specific clinical symptoms at early stages that resemble Acid Peptic Diseases (APDs). Despite recent efforts, a simple, liquid biopsy-based, multi-protein panel pre-diagnostic assay that can differentiate GCs from APDs is lacking. Parallelly, Mass Spectrometry (MS)-based targeted proteomics methods including Multiple Reaction Monitoring (MRM) are being progressively utilised as method-of-choice to build Laboratory Developed Tests (LDTs). An MS-MRM LDT that can quantify a panel of serum proteins was developed and tested in 135 serum samples from treatment-naïve cases of GCs, APDs, and healthy individuals.
HostingRepository	PRIDE
AnnounceDate	2025-09-18
AnnouncementXML	Submission_2025-09-17_23:36:06.468.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Keshava Prasad T. S.
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q TRAP

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-28 03:09:27	ID requested
⏵ 1	2025-09-17 23:36:07	announced

10.1021/acs.jproteome.5c00547;

Ramesh P, Upadhyay SS, Thomas SD, Sorake CJ, M K G, Shetty VV, Modi PK, Shetty R, Vijayakumar M, Codi JAK, Prasad TSK, Differentiating Gastric Cancers from Acid Peptic Diseases through Integrative Targeted Proteomics and Machine Learning Approaches. J Proteome Res, 24(10):5159-5176(2025) [pubmed]

submitter keyword: Laboratory Developed Test,Multiple reaction monitoring, Gastric Cancer, QTRAP 6500

Keshava Prasad
contact affiliation	Professor and Deputy Director, Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India
contact email	keshav@ibioinformatics.org
lab head
Keshava Prasad T. S.
contact affiliation	Professor and Deputy Director, Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India
contact email	keshav@ibioinformatics.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD064371

PRIDE project URI

• PRIDE
  1. PXD064371
     1. Label: PRIDE project
     2. Name: Multiple reaction monitoring assay for differentiating gastric cancer from acid peptic diseases