⮝ Full datasets listing
PXD064358-1
PXD064358 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | XAGE1B is a transcriptional regulator that acts via liquid-liquid phase separation to promote lung adenocarcinoma oncogenesis |
| Description | Lung adenocarcinoma (LUAD) is one of the top culprits of cancer-associated deaths worldwide, but its molecular underpinnings and disease mechanisms are not well characterized. Cancer cells can aberrantly reactivate embryonic or germline genes to drive oncogenic gene expression programs and promote phenotypic plasticity. An important but under-studied class of embryonic genes are cancer-testis antigen (CTA) genes. Due to their restricted expression in the germline and various cancers but not in normal adult tissues, CTAs have garnered immense interest for their potential as diagnostic biomarkers and therapeutic targets, yet their biochemical features and tumorigenic functions remain unknown. In this study, we report a gene regulatory role of XAGE1B, an under-explored CTA that we discovered to be highly upregulated in LUAD compared to normal lung tissue. XAGE1B contains intrinsically disordered regions (IDRs) that confer its liquid-liquid phase separation (LLPS) ability, which in turn promotes LUAD oncogenesis. Moreover, XAGE1B binds and enhances the LLPS capability of the transcriptional coactivator ARGLU1 within nuclear speckles, whereas IDR-lacking XAGE1B mutants are unable to bind ARGLU1, consequently impinging on LUAD development. We further showed that the gene regulatory function of XAGE1B is transcriptionally dependent on ARGLU1. Importantly, XAGE1B holds significant therapeutic value due to its exclusive expression in tumors but not in healthy cells, making it likely dispensable for normal adult tissues and raising its prospect as a viable targeted therapeutic with minimal toxicity. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-05-28 |
| AnnouncementXML | Submission_2026-05-27_08:00:21.495.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Radoslaw Sobota |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | L-methionine sulfoxide; S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; unknown modification; unknown modification; deamidated L-asparagine; deamidated L-glutamine |
| Instrument | instrument |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-05-28 01:43:27 | ID requested | |
| ⏵ 1 | 2026-05-27 08:00:22 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Lung cancer, LLPS, CTA, proteomics, TMT |
Contact List
| Wee Wei Tee | |
|---|---|
| lab head | |
| Radoslaw Sobota | |
| contact affiliation | IMCB A-STAR Singapore |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003836/ |
