PXD064235 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Unravel cellular heterogeneity in IDH1-mutant low-grade glioma cell Lines |
| Description | IDH1-mutant low-grade glioma are slow growing brain tumours arising from glial cells. They are subdivided in two groups; oligodendrogliomas and astrocytomas. They are characterizing by an intra-tumoral cellular heterogeneity. Previous studies have shown that at least 3 populations can be found in these tumours; astrocyte-like cells, oligodendrocyte-like cells and stem-like cells. Among these populations, some cells seem to be in a quiescent-like state, where others are mitotic. However, the correlation between glioma cell phenotype and cell cycle is still not fully explored. Here, using a low-grade glioma cell line named LGG275 published in Cancers 2021, 13(9), 2107; https://doi.org/10.3390/cancers13092107, we provided a method to sort at least two populations; the astrocyte-like cells and the oligodendrocyte-like cells, based on two extracellular markers, in a patient derived astrocytoma cell line. Proteomic analysis of these two populations as revealed that one is associated to a quiescent state, is plastic and can drive cellular heterogeneity, where the other is associated to an active state, and has a role in stem cell maintenance. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-22 |
| AnnouncementXML | Submission_2026-07-22_06:13:43.572.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Functional Proteomics Platform FPP |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-05-23 05:46:34 | ID requested | |
| ⏵ 1 | 2026-07-22 06:13:44 | announced | |
Publication List
Keyword List
| submitter keyword: Human, quiescence, cell Lines, glioma cells, cellular heterogeneity, low-grade glioma |
Contact List
| Jean-Philippe Hugnot |
|---|
| contact affiliation | Institute of Functional Genomics, Univ. Montpellier, CNRS, INSERM, Montpellier, France |
| contact email | jean-philippe.hugnot@umontpellier.fr |
| lab head | |
| Functional Proteomics Platform FPP |
|---|
| contact affiliation | FPP CNRS |
| contact email | contact@fpp.cnrs.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD064235 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD064235
- Label: PRIDE project
- Name: Unravel cellular heterogeneity in IDH1-mutant low-grade glioma cell Lines
