⮝ Full datasets listing
PXD064232-1
PXD064232 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quantitative Mass Spectrometry-Based Profiling of Cell Surface and Crude Membrane Proteins in Cisplatin-Resistant Triple-Negative Breast Cancer Cells |
| Description | This dataset includes cell surface (CSP) and crude membrane (CM) proteomic profiles of cisplatin-resistant and sensitive triple-negative breast cancer (TNBC) cell lines generated using data-independent acquisition (DIA) mass spectrometry workflows. Surface proteins were selectively enriched using membrane-impermeable biotinylation and affinity purification, while crude membrane proteins were isolated through differential ultracentrifugation. LC-MS/MS analysis was performed to identify and quantify differentially expressed proteins associated with cisplatin resistance. The dataset provides valuable insights into altered surfaceome and membrane proteome dynamics that underlie drug resistance mechanisms in TNBC, and highlights potential biomarkers and therapeutic targets for overcoming chemoresistance. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-05-23 |
| AnnouncementXML | Submission_2026-05-22_08:00:11.225.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Shashwati |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide |
| Instrument | instrument |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-05-23 03:51:01 | ID requested | |
| ⏵ 1 | 2026-05-22 08:00:11 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Triple-negative breast cancer, cisplatin resistance, surfaceome, membrane proteomics, LC-MS/MS, DIA, chemo-resistance markers |
Contact List
| Prof. Sanjeeva Srivastava | |
|---|---|
| lab head | |
| Shashwati | |
| contact affiliation | IIT Bombay |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003825/ |
