PXD064206-1

PXD064206 is an original dataset announced via ProteomeXchange.

Title	Manganese-modulated proteome and phospho-proteome of the opportunistic yeast Candida albicans
Description	The ability of the opportunistic yeast Candida albicans to acquire and maintain homeostatic levels of manganese (Mn), particularly in the metal-limited host environment, is an important determinant of its fitness. Although significant focus has been given to mechanisms of iron and copper acquisition and their roles in C. albicans fitness, little is known about how this yeast maintain and control Mn homeostasis. Here, we presented a comparative proteomic and phospho-proteomic analysis in C. albicans cells experiencing Mn starvation. Both proteome and phosphoproteome of the C. albicans reference strain SC5314 growing in Mn-depleted medium were compared to those of cells thriving in Mn-repleted medium. Samples were collected in four biological replicates at two time-points (5 and 90 min). LC–MS/MS identified approximately 1500 differentially abundant proteins and over 140 phosphorylated proteins.
HostingRepository	PRIDE
AnnounceDate	2025-06-12
AnnouncementXML	Submission_2025-06-12_04:10:15.019.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Manon Henry
SpeciesList	scientific name: Candida albicans (Yeast); NCBI TaxID: 5476;
ModificationList	phosphorylated residue
Instrument	Orbitrap Exploris 240

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-22 11:47:41	ID requested
⏵ 1	2025-06-12 04:10:15	announced

Dataset with its publication pending

submitter keyword: Candida albicans

Metal homeostasis

Manganese starvation

Proteomic

Phosphoproteome

Adnane Sellam
contact affiliation	Montreal Heart Institute/Institut de Cardiologie de Montréal, Université de Montréal, Montréal, QC, Canada Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada
contact email	adnane.sellam@umontreal.ca
lab head
Manon Henry
contact affiliation	Université de Montréal
contact email	manon.henry@umontreal.ca
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD064206
     1. Label: PRIDE project
     2. Name: Manganese-modulated proteome and phospho-proteome of the opportunistic yeast Candida albicans