PXD064173 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Biotope-dependent High Level Resistance to Reactive Oxygen Species, Antibiotic Tolerance, and Virulence of Staphylococcus aureus |
| Description | The human and livestock pathogen Staphylococcus aureus poses a major clinical challenge due to antibiotic treatment failure. Its resilience is mainly attributed to antibiotic resistance and tolerance mechanisms related to persistence. Here we investigate how two infection-relevant conditions, milk and serum, shape S. aureus pathogenic properties and capacity to withstand environmental stresses. Milk- versus serum-grown bacteria show gross differences in envelope physical properties, membrane fatty acid composition and rigidity, and pigment production, and display distinct proteomic profiles. Compared to serum, milk adaptation of S. aureus confers extreme resistance to ROS damage, pronounced antimicrobial tolerance, and accelerated killing in a larvae infection model. High level S. aureus pigmentation in whole milk is stimulated by milk lipids, and is responsible for high ROS resistance. The remarkable robustness of S. aureus in a milk biotope may signal the need to adjust antibiotic regimens when treating mastitis infections in humans and livestock. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-25 |
| AnnouncementXML | Submission_2026-05-25_13:35:08.382.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zoran Minic |
| SpeciesList | scientific name: Staphylococcus aureus; NCBI TaxID: NEWT:1280; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-05-21 17:24:32 | ID requested | |
| ⏵ 1 | 2026-05-25 13:35:08 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Food and Nutrition (B/D-HPP), Human Proteome Project |
| submitter keyword: Serum, antibiotic resistance , LC-MS, Milk,Staphylococcus aureus |
Contact List
| Jasmina Vidic |
|---|
| contact affiliation | Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy en Josas, France |
| contact email | jasmina.vidic@inrae.fr |
| lab head | |
| Zoran Minic |
|---|
| contact affiliation | John L. Holmes Mass Spectrometry Facility, University of Ottawa |
| contact email | zminic@uottawa.ca |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD064173 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD064173
- Label: PRIDE project
- Name: Biotope-dependent High Level Resistance to Reactive Oxygen Species, Antibiotic Tolerance, and Virulence of Staphylococcus aureus
