PXD064155 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | proteomics analysis of SDE2UBL base activity based probe immunoprecipitation |
| Description | SDE2, a highly conserved and essential gene required for genome maintenance, coordinates essential processes ranging from pre-mRNA splicing and ribosome biogenesis to DNA repair and replication stress response. It is expressed as a full-length precursor (SDE2FL,) bearing an N-terminal ULD, which is proteolytically cleaved to generate two protein fragments, SDE2UBL and the larger C-terminal domain (SDE2CT). Here we report the use of activity-based probe to aid the identification of the protease responsible for SDE2 processing, resolving a previously uncharacterized mechanism of post-translational regulation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-24 |
| AnnouncementXML | Submission_2026-06-24_06:18:45.037.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Frederic Lamoliatte |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-05-21 08:40:02 | ID requested | |
| ⏵ 1 | 2026-06-24 06:18:45 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: ubiquitin-like fusion proteins,SDE2, activity-based probe, proteolysis, immunoprecipitation |
Contact List
| Chiara Maniaci |
|---|
| contact affiliation | Medical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK. |
| contact email | CManiaci001@dundee.ac.uk |
| lab head | |
| Frederic Lamoliatte |
|---|
| contact affiliation | University of Dundee |
| contact email | flamoliatte001@dundee.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD064155 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD064155
- Label: PRIDE project
- Name: proteomics analysis of SDE2UBL base activity based probe immunoprecipitation
