PXD064059-1

PXD064059 is an original dataset announced via ProteomeXchange.

Title	Identification of plasma exosomal protein markers associated with diabetic retinopathy progression by proteomic analysis
Description	Protein biomarkers derived from plasma exosome have been extensively identified in various diseases. This study aimed to explore the biomarkers at different stages of diabetes retinopathy (DR) progression. Two cohorts, discovery and validation cohorts, were included in this study. The discovery cohort was used for proteomic analysis to screen differentially expressed proteins (DEPs). Hub proteins were identified by Wilcox.test, and their correlation with clinical characteristics were further analyzed. The validation cohort was used for enzyme-linked immunosorbent assay (ELISA) to verify the expression of hub proteins. Receiver operator characteristic (ROC) curve was conducted to evaluate the diagnostic values of hub proteins for DR progression. The correlation with clinical indicators was further analyzed.
HostingRepository	PRIDE
AnnounceDate	2025-06-11
AnnouncementXML	Submission_2025-06-11_00:17:00.999.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hang Wu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	maXis

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-19 08:16:38	ID requested
⏵ 1	2025-06-11 00:17:01	announced

Dataset with its publication pending

submitter keyword: diabetes retinopathy, proteomics, plasma exosomes, biomarkers

Hang Wu
contact affiliation	Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, China
contact email	whxwyy9110681@sina.com
lab head
Hang Wu
contact affiliation	Research Center
contact email	whxwyy9110681@sina.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD064059

PRIDE project URI

• PRIDE
  1. PXD064059
     1. Label: PRIDE project
     2. Name: Identification of plasma exosomal protein markers associated with diabetic retinopathy progression by proteomic analysis