PXD064030 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Sexual Dimorphism of Plasma Proteomes in Human Calcific Aortic Valve Stenosis |
| Description | Females are underrepresented in studies of calcific aortic valve stenosis (CAVS), leading to delay in timely intervention and increased mortality. Histopathology demonstrates female CAVS presents with decreased valvular calcification but increased fibrosis and severity of symptoms. CAVS plasma samples (n=20 females, n=30 males) were analyzed for circulating sex-specific biomarkers via LC-MS/MS. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-25 |
| AnnouncementXML | Submission_2025-11-24_16:34:58.845.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD064030 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Cassandra Clift |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | L-methionine sulfoxide; acetylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-05-18 18:41:27 | ID requested | |
| ⏵ 1 | 2025-11-24 16:34:59 | announced | |
Publication List
| 10.6019/PXD064030; |
| 10.1161/atvbaha.125.322560; |
| Clift CL, Blaser MC, Bartoli-Leonard F, Schlotter F, Higashi H, Kuraoka S, Kasai T, Turner ME, Pham T, Perez KA, Robson SC, Body SC, Muehlschlegel JD, Aikawa M, Singh SA, Aikawa E, Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis-Brief Report. Arterioscler Thromb Vasc Biol, 45(10):1928-1934(2025) [pubmed] |
Keyword List
| submitter keyword: Human, LC-MSMS, calcification, aortic valve, fibrosis, sex disparities |
Contact List
| Elena Aikawa |
|---|
| contact affiliation | Brigham and Women's Hospital, Harvard Medical School |
| contact email | eaikawa@bwh.harvard.edu |
| lab head | |
| Cassandra Clift |
|---|
| contact affiliation | Harvard Medical School, Brigham and Women's Hospital |
| contact email | cliftc@musc.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD064030 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD064030
- Label: PRIDE project
- Name: Sexual Dimorphism of Plasma Proteomes in Human Calcific Aortic Valve Stenosis
