PXD064023 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Deciphering stiffness-driven changes in colorectal cancer by proteomics |
| Description | Tumor stiffening plays a pivotal role in cancer progression. Increased tumor stiffness, resulting from interactions between cancer cells and their surrounding microenvironment, alters the tumor's mechanical properties and significantly impacts cancer growth and metastasis, the primary cause of cancer-related deaths. Despite the importance of tumor stiffness, systematic studies exploring its effect on prote in dysregulation are limited. In this study, focused on colorectal cancer, we show by in-depth proteomics that matrix stiffness significantly alters the expression of secreted proteins, while intracellular protein levels remain largely unaffected. Functional assays reveal that the changes observed by proteomics in the secretome, driven by matrix stiffness, enhance cell migration, angiogenesis, and matrix remodeling, which collectively would contribute to a more aggressive cancer phenotype in a real scenario. Our findings emphasize the critical role of matrix stiffness in driving colorectal cancer progression through changes in the secretome, offering valuable insights for the development of biomechanical cancer therapies. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-25 |
| AnnouncementXML | Submission_2026-01-24_16:07:58.387.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ana Montero Calle |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-05-17 18:16:26 | ID requested | |
| ⏵ 1 | 2026-01-24 16:07:58 | announced | |
Publication List
Keyword List
Contact List
| Rodrigo Barderas |
|---|
| contact affiliation | Chronic Disease Programme, UFIEC, Instituto de Salud Carlos III, 28220 Madrid, Spain. |
| contact email | r.barderasm@isciii.es |
| lab head | |
| Ana Montero Calle |
|---|
| contact affiliation | Instituto de Salud Carlos III |
| contact email | ana.monteroc@isciii.es |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD064023
- Label: PRIDE project
- Name: Deciphering stiffness-driven changes in colorectal cancer by proteomics
