PXD063893-1

PXD063893 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Androgenic Effects of 11-oxyandrogens in Castration-Resistant Prostate Cancer
Description	Investigations of CRPC cell models demonstrate that 11-ketotestesterone (11KT) and 11-hydroxytestosterone (11OHT) drive robust AR-mediated proliferative responses and significantly modulate gene and protein expression profiles, paralleling canonical androgens. They also exhibit unique transcriptional and post-transcriptional effects that include potential AR-independent pathways. Furthermore, the AR antagonist enzalutamide effectively inhibits their androgenic actions, suggesting they are primarily AR-mediated.
HostingRepository	MassIVE
AnnounceDate	2025-10-10
AnnouncementXML	Submission_2025-10-10_06:42:09.484.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michele Rouleau
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	CarbamidomethylDTT; Met-loss; Homocysteic_acid
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-13 13:28:21	ID requested
⏵ 1	2025-10-10 06:42:10	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: DIAnn, CRPC proteomics, 11-oxygenated androgens, androgen receptor, enzalutamide, DatasetType:Proteomics

submitter keyword: DIAnn, CRPC proteomics, 11-oxygenated androgens, androgen receptor, enzalutamide, DatasetType:Proteomics

Contact List

Chantal Guillemette
contact affiliation	CHU de Quebec Research Center - Universite Laval
contact email	chantal.guillemette@crchudequebec.ulaval.ca
lab head
Michele Rouleau
contact affiliation	CHU de Qu�bec Research center
contact email	michele.rouleau@crchudequebec.ulaval.ca
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v09/MSV000097860/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v09/MSV000097860/