PXD063822 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Structural analysis of the CSN complex to understand its inhibition mechanism |
| Description | We performed interaction and structural analyses to unravel the molecular mechanisms underlying CSN inhibition. Various methods including Cryo-EM, quantitative mass spectrometry and biochemical assays have been employed to define inhibitor-induced interaction and structural changes of the CSN complex in vitro and in cells. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-22 |
| AnnouncementXML | Submission_2025-11-21_17:59:34.694.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Clinton Yu |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-05-09 15:04:26 | ID requested | |
| ⏵ 1 | 2025-11-21 17:59:35 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: CSN, quantitative MS, CRLs, protein ubiquitination, neddylation, Cryo-EM,COP9 signalsome |
Contact List
| Dr. Lan Huang |
|---|
| contact affiliation | Department of Physiology & Biophysics, University of California, Irvine, Irvine, California, USA |
| contact email | lanhuang@uci.edu |
| lab head | |
| Clinton Yu |
|---|
| contact affiliation | University of California, Irvine |
| contact email | clinton.yu@uci.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD063822 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD063822
- Label: PRIDE project
- Name: Structural analysis of the CSN complex to understand its inhibition mechanism
