PXD063817-1

PXD063817 is an original dataset announced via ProteomeXchange.

Title	Dynamic exchange of CRL4 regulated by CAND1 and CAND2
Description	CAND1 and CAND2 have been established as exhange factors for CRL1s, however, how they regulate the dynamic exchange of CRL4s remains not fully understood. This project aims to study and compare the effect of CAND proteins on the exchange levels of multiple DCAFs, thus providing insights into the function of these key Cullin-binding proteins in an important family of Cullin-RING ligases.
HostingRepository	PRIDE
AnnounceDate	2026-02-12
AnnouncementXML	Submission_2026-02-12_08:42:14.440.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kankan Wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	6x(13)C labeled residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-09 10:22:52	ID requested
⏵ 1	2026-02-12 08:42:14	announced

Dataset with its publication pending

submitter keyword: SILAC

Human

Cullin-RING ubiquitin ligases

XING LIU
contact affiliation	Department of Biochemistry, Purdue University
contact email	xingliu@purdue.edu
lab head
Kankan Wang
contact affiliation	Purdue University
contact email	wang4196@purdue.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD063817

PRIDE project URI

• PRIDE
  1. PXD063817
     1. Label: PRIDE project
     2. Name: Dynamic exchange of CRL4 regulated by CAND1 and CAND2