PXD063794 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The potential role of extracellular vesicles derived from human myogenic precursor cells |
| Description | The physiological decline in skeletal muscle mass, power and function, known as sarcopenia, presents significant challenges for aged subjects. Recently, skeletal muscle is recognised as a se-cretory organ as human myogenic precursor cells (hMPCs) can release extracellular vesicles (EVs). This work aims to investigate the potential messenger of EVs produced from hMPCs in the context of skeletal muscle aging. The EVs have been isolated from the culture media of hMPCs isolated from Vastus Lateralis muscle biopsies obtained from young and elderly subjects. The EVs from young and elderly samples were: characterised for their size and concentration, studied for mus-cle-specific miRNAs expression and proteomic profile in order to delineate potential signalling pathways carried by the EVs. Based on previous study we wonder if EVs were able to modulate proliferative and regenerative properties of hMPCs depending on the donor age. To the purpose elderly hMPCs were stimulated with young EVs and their viability and differentiative features were analyzed; as well as vice versa. The results collected showed that hMPCs are capable of re-leasing EVs and that their cargo can be modulated by the donor age. In addition, the application of EVs on hMPCs cell cultures highlighted their ability to modulate both cell differentiation and viability. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-24 |
| AnnouncementXML | Submission_2026-08-23_16:13:59.108.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Federica Di Marco |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | monohydroxylated residue; deaminated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-05-09 02:46:39 | ID requested | |
| ⏵ 1 | 2026-08-23 16:13:59 | announced | |
Publication List
Keyword List
| submitter keyword: extracellular vesicles, miRNA, human myogenic precursor cells |
Contact List
| Rosa Mancinelli |
|---|
| contact affiliation | 1 Dept Neuroscience, Imaging and Clinical Sciences, “G. d’Annunzio” University Chieti-Pescara, Italy 2 Interuniversity Institute of Myology, Italy; lorenzo.marramiero@unich.it; es.difilippo@unich.it; tiziana@pietrangelo@unich.it; stefania.fulle@unich.it; rosa.mancinelli@unich.it 3 Functional Evaluation Laboratory, “G. d’Annunzio” University Chieti-Pescara, Italy |
| contact email | rosa.mancinelli@unich.it |
| lab head | |
| Federica Di Marco |
|---|
| contact affiliation | University of "G. d' Annunzio" Chieti - Pescara |
| contact email | federica.dimarco@unich.it |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD063794
- Label: PRIDE project
- Name: The potential role of extracellular vesicles derived from human myogenic precursor cells
