PXD063777 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Dimethyl fumarate targets in macrophages |
| Description | To understand the molecular mechanism underlying DMF’s inhibition of NLRP3 inflammasome in macrophage, we conducted chemoproteomics to identify the specific protein targets of DMF. We used MMFyne, a previously reported clickable DMF analogue to label and help identify potential DMF target proteins in macrophages. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-25 |
| AnnouncementXML | Submission_2026-05-24_16:34:32.014.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Qin Fu |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-05-08 13:11:55 | ID requested | |
| ⏵ 1 | 2026-05-24 16:34:32 | announced | |
Publication List
| 10.1016/j.chembiol.2026.03.016; |
| Zhang Y, Lindner H, So B, Chen Z, Li H, Xu J, Wang J, Xu J, Petre AM, Distefano MD, N, ú, ñ, ez G, Lin H, NEK7 Cys298 is important for NLRP3 inflammasome and targetable by dimethyl fumarate. Cell Chem Biol, 33(5):711-719.e4(2026) [pubmed] |
Keyword List
| submitter keyword: macrophage,dimethyl fumarate |
Contact List
| Qin Fu |
|---|
| contact affiliation | Cornell University |
| contact email | qf44@cornell.edu |
| lab head | |
| Qin Fu |
|---|
| contact affiliation | Cornell University |
| contact email | qf44@cornell.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD063777 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD063777
- Label: PRIDE project
- Name: Dimethyl fumarate targets in macrophages
