PXD063726-1

PXD063726 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	LC-MS data of IM95 gastric cancer cells following YAP degradation by bioPROTAC
Description	In this study, through naïve nanobody phage library screening, we have identified multiple nanobodies against human YAP with high affinity and specificity. The YAP nanobody was then fused to the RING domain of RNF4, creating a bio-Proteolysis-Targeting Chimera (bioPROTAC) molecule capable of selectively targeting endogenous YAP for ubiquitin-mediated degradation.
HostingRepository	PRIDE
AnnounceDate	2025-11-03
AnnouncementXML	Submission_2025-11-02_16:25:48.957.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gui-Ming Zhang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-07 07:44:40	ID requested
⏵ 1	2025-11-02 16:25:50	announced

Publication List

10.1038/s41467-025-64426-7;
Zhou R, Wang H, Zhang GM, Liu Y, Liu XL, Li Z, Shi G, Yuan J, Qu C, Li Y, Chen L, Huang J, Zhou H, Dai L, Bai C, Wang J, Yu L, Li Z, Li YL, Targeted degradation of endogenous YAP by nanobody bioPROTAC inhibits tumor progression. Nat Commun, 16(1):9374(2025) [pubmed]

10.1038/s41467-025-64426-7;

Zhou R, Wang H, Zhang GM, Liu Y, Liu XL, Li Z, Shi G, Yuan J, Qu C, Li Y, Chen L, Huang J, Zhou H, Dai L, Bai C, Wang J, Yu L, Li Z, Li YL, Targeted degradation of endogenous YAP by nanobody bioPROTAC inhibits tumor progression. Nat Commun, 16(1):9374(2025) [pubmed]

Keyword List

submitter keyword: gastric cancer cells,YAP,bioPROTAC

submitter keyword: gastric cancer cells,YAP,bioPROTAC

Contact List

Gui-Ming Zhang
contact affiliation	NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University,Guangzhou 510515, P.R.China
contact email	1653352626@qq.com
lab head
Gui-Ming Zhang
contact affiliation	Southern Medical University
contact email	1653352626@qq.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD063726
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD063726

PRIDE project URI

Repository Record List

[ + ]