PXD063582 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Probing the CaV1.2 interactome in heart failure identifies a positive modulator of inotropy and lusitropy |
| Description | Maladaptive changes in the function, expression and localization of proteins involved in calcium-handling worsen the impaired contractility of systolic heart failure (HF). Standard proteomics techniques require cell lysis and so are unable to characterize changes specific to the critical sub-cellular domain bounded by the T-tubule and the sarcoplasmic reticulum, known as the cardiac dyad. Traditional approaches are also less likely to capture low-affinity protein-protein interactions on lipid membranes. To improve our understanding of heart failure pathophysiology, we applied proximity proteomics to cardiac dyads of mice with ischemic cardiomyopathy. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-15 |
| AnnouncementXML | Submission_2026-04-15_15:56:41.257.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD063582 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Marian Kalocsay |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-05-03 23:25:15 | ID requested | |
| ⏵ 1 | 2026-04-15 15:56:41 | announced | |
Publication List
Keyword List
| submitter keyword: Gal-1 cardiac inotropy lusitropy proximity labeling |
Contact List
| Jared Kushner |
|---|
| contact affiliation | Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA |
| contact email | jsk2018@cumc.columbia.edu |
| lab head | |
| Marian Kalocsay |
|---|
| contact affiliation | The University of Texas MD Anderson Cancer Center
Department of Experimental Radiation Oncology |
| contact email | mkalocsay@mdanderson.org |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD063582 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD063582
- Label: PRIDE project
- Name: Probing the CaV1.2 interactome in heart failure identifies a positive modulator of inotropy and lusitropy
