PXD063553-1

PXD063553 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Effects of hypoxia on brain protein expression in a mouse model of Parkinson's disease
Description	The purpose of this study was to evaluate whether chronic, continuous hypoxia (breathing 11% FIO2) would improve neurodegenerative disease in a mouse model of Parkinson's disease, which was modeled through intrastriatal injection of a-synuclein preformed fibrils (PFFs). We find that chronic, continuous hypoxia helps to prevent further neurodegeneration and alleviate neurological disease.
HostingRepository	PRIDE
AnnounceDate	2025-07-14
AnnouncementXML	Submission_2025-07-14_13:19:49.374.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD063553
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Timothy Durham
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Orbitrap Eclipse; Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-02 03:43:14	ID requested
⏵ 1	2025-07-14 13:19:49	announced

Publication List

10.6019/PXD063553;
10.1038/S41593-025-02010-4;

10.6019/PXD063553;

10.1038/S41593-025-02010-4;

Keyword List

submitter keyword: Parkinson Disease, brain, hypoxia, mouse, PFF, substantia nigra

submitter keyword: Parkinson Disease, brain, hypoxia, mouse, PFF, substantia nigra

Contact List

Vamsi Mootha
contact affiliation	Mootha Lab Department of Molecular Biology Massachusetts General Hospital Boston, MA, USA
contact email	vamsi_mootha@hms.harvard.edu
lab head
Timothy Durham
contact affiliation	Broad Institute
contact email	tdurham@broadinstitute.org
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD063553
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD063553

PRIDE project URI

Repository Record List

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