PXD063486 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Streptococcus pneumoniae biomarker identification by surface shaving and bottom-up mass spectrometry-based proteomics |
| Description | In this study, genomics- and proteomics-based approaches were used for the identification of Streptococcus pneumoniae potential biomarkers for diagnostics and prospective targets for treatment. Through a Pan-genome analyses 11 strains from the CCUG demonstrating genetic variability within the species were selected for a proteomic characterization. Mass spectrometry-based proteomics in combination with bacterial surface shaving were used to study the surface proteome of S. pneumoniae. The 11 strains were analyzed in triplicates by proteotyping (typing and characterization of species by mass spectrometry-based proteomics) and bioinformatic approaches, including the Microorganism Identification and Classification, were used to validate the expressed proteins and peptide biomarkers. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-15 |
| AnnouncementXML | Submission_2025-12-14_16:48:23.521.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD063486 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Roger Karlsson |
| SpeciesList | scientific name: Streptococcus pneumoniae; NCBI TaxID: NEWT:1313; scientific name: Bacteria; NCBI TaxID: NCBITaxon:2; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos; Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-30 02:39:16 | ID requested | |
| ⏵ 1 | 2025-12-14 16:48:24 | announced | |
Publication List
| 10.1021/acs.jproteome.5c00716; |
| 10.6019/PXD063486; |
| Acha Alarcon L, Segu, í G, Pi, ñ, eiro-Iglesias B, Svetlicic E, Kondori N, Gomila M, Moore ERB, Karlsson R, Specific Proteins by Surface-Shaving Proteomics. J Proteome Res, 24(12):6154-6173(2025) [pubmed] |
Keyword List
| submitter keyword: proteomics, surface-shaving, bottom-up mass spectrometry, LPI, biomarkers,Streptococcus pneumoniae |
Contact List
| Roger Karlsson |
|---|
| contact affiliation | Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden. Department of Clinical Microbiology, Sahlgrenska University Hospital, Region Västra Götaland, 41345 Gothenburg, Sweden. |
| contact email | roger.karlsson@vgregion.se |
| lab head | |
| Roger Karlsson |
|---|
| contact affiliation | Clinical microbiology, Sahlgrenska University Hospital |
| contact email | roger.karlsson@vgregion.se |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD063486 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD063486
- Label: PRIDE project
- Name: Streptococcus pneumoniae biomarker identification by surface shaving and bottom-up mass spectrometry-based proteomics
