PXD063417-1

PXD063417 is an original dataset announced via ProteomeXchange.

Title	Mus musculus (A/J) lung infection with Cryptococcus neoformans (serotype A) clinical isolates
Description	To predict the outcomes of disseminated fungal disease, a deeper understanding of host-pathogen interactions at the site of infection is needed to identify targets for clinical intervention and diagnostic development. Cryptococcus neoformans is the causative agent of cryptococcosis, the largest infectious killer of individuals living with HIV. Cryptococcal infection begins in the lungs, with loss of immunological control leading to disseminated central nervous system disease and death. Using advanced mass spectrometry-based proteomic techniques, in vivo infection models, and patient-derived clinical strains, we explored the proteomic profiles of C. neoformans infections related to differences in strain virulence. Our findings reveal the non-lethal latent infection produces a proteomic response that drastically differs from those caused by lethal infections, and that the proteomic profiles of typical and hypervirulent infections are surprisingly similar despite differences in time-to-death.
HostingRepository	PRIDE
AnnounceDate	2025-09-18
AnnouncementXML	Submission_2025-09-17_19:49:39.197.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jovany Betancourt
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Cryptococcus neoformans var. grubii; NCBI TaxID: 178876;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 240

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-28 23:13:38	ID requested
⏵ 1	2025-09-17 19:49:39	announced

10.1128/MSYSTEMS.00751-25;

submitter keyword: Infection, Cryptococcus neoformans,Mouse, Lung, LC-MS/MS

Kirsten Nielsen
contact affiliation	Professor Center for One Health Research Department of Biomedical Sciences and Pathobiology Office of Research and Innovation Virginia Tech University
contact email	kirstennielsen@vt.edu
lab head
Jovany Betancourt
contact affiliation	University of Minnesota
contact email	betan041@umn.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD063417

PRIDE project URI

• PRIDE
  1. PXD063417
     1. Label: PRIDE project
     2. Name: Mus musculus (A/J) lung infection with Cryptococcus neoformans (serotype A) clinical isolates