PXD063403-1

PXD063403 is an original dataset announced via ProteomeXchange.

Title	Uncovering Systemic Biomarkers of Intervertebral Disc Degeneration through Plasma Proteomics
Description	Intervertebral disc (IVD) degeneration is a leading contributor to chronic low back pain, a condition with significant socioeconomic and healthcare burdens worldwide. Despite its prevalence, early diagnosis and effective, targeted therapies for IVD degeneration remain limited, largely due to an incomplete understanding of the molecular mechanisms underlying disease onset and progression. Traditionally, research has focused on the local disc environment, but emerging evidence suggests that systemic factors — particularly those circulating in the bloodstream — may play a critical role in disc homeostasis and degeneration. The plasma proteome, representing a dynamic collection of circulating proteins, offers a powerful window into systemic physiological states. Advances in high-throughput proteomics now make it possible to detect subtle yet biologically significant shifts in circulating protein profiles, potentially unveiling biomarkers indicative of tissue-specific changes, including those occurring in the intervertebral disc. However, the systemic proteomic landscape associated with IVD degeneration remains underexplored. This project aims to leverage plasma proteomics to uncover systemic protein biomarkers linked to IVD degeneration. By comparing the plasma profiles of individuals with varying degrees of disc degeneration to those of healthy controls, we seek to identify protein signatures reflective of disc pathology. These findings could not only improve early detection and monitoring strategies but also provide novel insights into systemic contributors to disc disease, paving the way for more personalized and effective therapeutic approaches.
HostingRepository	PRIDE
AnnounceDate	2025-12-15
AnnouncementXML	Submission_2025-12-15_11:44:57.283.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chitraa Tangavel
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	carbamoylated residue; S-carboxamidoethyl-L-cysteine; phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-28 10:25:11	ID requested
⏵ 1	2025-12-15 11:44:58	announced

10.1186/s12014-025-09563-3;

Nayagam SM, Palraj ND, Eswaran M, Selvaraj G, Rajendran S, Ramachandran K, Arunachalam D, Tangavel C, K S SA, Raveendran M, Rajasekaran S, Do microenvironmental changes in degenerative disc disease reflect in systemic circulation? A proteomic investigation. Clin Proteomics, 22(1):48(2025) [pubmed]

submitter keyword: Human, PLasma Proteomics, DDD, Biomarker, Intervertebral disc

Dr Chitraa Tangavel
contact affiliation	Research Scientist, Ganga Orthopedic Research and Education Foundation, 187, Mettupalayam Road, Kavundampalayam, Coimbatore- 641030, Tamil Nadu, India
contact email	cthangavel@gmail.com
lab head
Chitraa Tangavel
contact affiliation	Research Scientist, Ganga Orthopedic Research and Education Foundation, 187, Mettupalayam Road, Kavundampalayam, Coimbatore- 641030, Tamil Nadu, India
contact email	cthangavel@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD063403

PRIDE project URI

• PRIDE
  1. PXD063403
     1. Label: PRIDE project
     2. Name: Uncovering Systemic Biomarkers of Intervertebral Disc Degeneration through Plasma Proteomics