PXD063370 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Spatial distribution of the proteome in the human body and in cancers |
| Description | A detailed, spatially resolved quantitative map of the human proteome is essential for a deeper understanding of human biology anddisease. Here we present a comprehensive human proteomic landscape, generated by profiling more than 13,000 proteinsacross 2,856 samples using data-independent acquisition mass spectrometry. The dataset spans 58 major tissue types, 251 specifictissue subtypes and 25 distinct carcinomas. This resource enables the depiction of spatially resolved proteome trajectories across tissuetypes and physiological states, including fetal, tumour, adjacent non-tumour and healthy adult tissue, thereby providing insight intoboth developmental processes and oncogenic progression. Furthermore, quantitative proteomics comparisons across diverse tissue typesand states facilitate the prediction of organ-specific toxicity, the identification of repurposable anticancer drug candidates and theprioritization of therapeutic targets for cancers. This study establishes a quantitative resource for navigating the proteome in the humanbody and in common cancers. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-21 |
| AnnouncementXML | Submission_2026-06-20_23:44:49.982.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Tiannan Guo |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF; timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-27 09:22:25 | ID requested | |
| ⏵ 1 | 2026-06-20 23:44:50 | announced | |
Publication List
Keyword List
| submitter keyword: quantitative proteomics |
| diaPASEF |
| mass spectrometry |
| cancer biomarkers |
Contact List
| Tiannan Guo |
|---|
| contact affiliation | Affiliated Hangzhou First People’s Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, Westlake University, Hangzhou, Zhejiang Province, China. Westlake Center for Intelligent Proteomics, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang Province, China. Research Center for Industries of the Future, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province, China. |
| contact email | guotiannan@westlake.edu.cn |
| lab head | |
| Tiannan Guo |
|---|
| contact affiliation | Westlake University |
| contact email | guotiannan@westlake.edu.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD063370 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD063370
- Label: PRIDE project
- Name: Spatial distribution of the proteome in the human body and in cancers
