PXD063324 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Tirzepatide reduces alcohol drinking, modulates reward processing, and alters lateral septum proteome in preclinical models of AUD |
| Description | This study explored the therapeutic potential of tirzepatide, a dual glucagon-like peptide-1 receptor (GLP-1R)/glucose-dependent insulinotropic polypeptide receptor (GIPR) agonist, in preclinical models of AUD, while elucidating the neurobiological mechanisms mediating its effects. Our methodological approach involved reward-related behaviors, alcohol consumption paradigms, and molecular techniques including neurochemical, neurophysiological, and proteome analysis in rodents. Tirzepatide administration attenuated alcohol-induced locomotor stimulation, conditioned place preference, and accumbal dopamine release. Global proteomic analysis revealed altered histone and chromatin regulatory proteins in the lateral septum of tirzepatide-treated alcohol-consuming rats. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-23 |
| AnnouncementXML | Submission_2026-01-23_02:47:59.855.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Johannes Fuchs |
| SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-25 04:54:10 | ID requested | |
| ⏵ 1 | 2026-01-23 02:48:00 | announced | |
Publication List
| 10.1016/j.ebiom.2025.106119; |
| Edvardsson CE, Adermark L, Gottlieb S, Alfreji S, Emous TA, Gouda Y, Thorsell A, Vuji, č, i, ć M, Aran, ä, s C, Benrick A, Wernstedt Asterholm I, Lopez MF, Becker HC, Jerlhag E, Tirzepatide reduces alcohol drinking and relapse-like behaviours in rodents. EBioMedicine, 124():106119(2026) [pubmed] |
Keyword List
| submitter keyword: alcohol. ethanol, TMT, Global quantitative proteomics,Tirzepatide, preclinical models |
Contact List
| Elisabet Jerlhag |
|---|
| contact affiliation | Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden |
| contact email | elisabet.jerlhag@pharm.gu.se |
| lab head | |
| Johannes Fuchs |
|---|
| contact affiliation | Gothenburg University |
| contact email | johannes.fuchs@gu.se |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD063324 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD063324
- Label: PRIDE project
- Name: Tirzepatide reduces alcohol drinking, modulates reward processing, and alters lateral septum proteome in preclinical models of AUD
