PXD063297-1

PXD063297 is an original dataset announced via ProteomeXchange.

Title	Unraveling the Regulatory Impact of Hnf1aos1 on Hepatic Homeostasis
Description	Long non-coding RNAs (lncRNAs) have emerged as crucial regulators of gene expression, playing significant roles in tissue development and disease progression. The antisense lncRNA Hnf1aos1 represents a particularly intriguing regulatory molecule in liver biology, functioning as a negative regulator of HNF1α and involved in cytochrome P450 enzyme regulation and epigenetic mechanisms. Despite the growing recognition of lncRNAs in liver diseases, the comprehensive role of Hnf1aos1 in liver function remains poorly understood. This study aims to investigate the effects of Hnf1aos1 knockdown on liver function, gene expression, and cellular processes using a mouse model to uncover potential therapeutic targets for liver disorders.
HostingRepository	PRIDE
AnnounceDate	2025-08-04
AnnouncementXML	Submission_2025-08-03_16:08:27.271.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jen Liddle
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-24 14:58:31	ID requested
⏵ 1	2025-08-03 16:08:28	announced

10.3390/ncrna11040052;

Armanios B, Jin J, Kolmel H, Laddha AP, Mishra N, Manautou JE, Zhong XB, Unraveling the Regulatory Impact of LncRNA Hnf1aos1 on Hepatic Homeostasis in Mice. Noncoding RNA, 11(4):(2025) [pubmed]

submitter keyword: Hepatocytes, HNF1a, liver, lncRNA, cytochrome P450

Dr. Jeremy Balsbaugh
contact affiliation	Proteomics & Metabolomics Facility, Center for Open Research Resources & Equipment University of Connecticut Storrs, CT 06269
contact email	jeremy.balsbaugh@uconn.edu
lab head
Jen Liddle
contact affiliation	University of Connecticut
contact email	jennifer.liddle@uconn.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD063297

PRIDE project URI

• PRIDE
  1. PXD063297
     1. Label: PRIDE project
     2. Name: Unraveling the Regulatory Impact of Hnf1aos1 on Hepatic Homeostasis