PXD063218 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Nanoparticle-enabled plasma proteomics of a preclinical atherosclerosis model reveals common signatures with human disease |
| Description | Coronary heart disease (CHD) accounts for one-third of deaths in the United States, with an annual economic burden exceeding $400 billion. Elevated plasma levels of low-density lipoprotein-cholesterol (LDL-C) is a major risk factor for CHD, through its promotion of atherosclerosis. Mutations in the LDL receptor (LDLR) are causal for familial hypercholesterolemia, inciting the Ldlr-/- murine model for atherosclerosis studies. Despite >3,000 reports using this model, the technical challenge of low volume blood draws from mice, on top of the limited detection range in plasma, have impeded efforts to identify circulating disease drivers. The recent advent of nanoparticle-dependent biofluid proteomics has enabled more sensitive monitoring of mouse tissue-associated disease drivers in plasma, offering insights into their relevance to human atherosclerosis. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-21 |
| AnnouncementXML | Submission_2026-08-20_20:00:07.924.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Sasha Singh |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-22 22:36:18 | ID requested | |
| ⏵ 1 | 2026-08-20 20:00:08 | announced | |
Publication List
| 10.1016/j.jacbts.2026.101649; |
| Delwarde C, Matamalas JT, Chelvanambi S, Kasai T, Shlayen G, Santinelli-Pestana DV, Zamani M, Aikawa E, Aikawa M, Singh SA, Nanoparticle-Enabled Plasma Proteomics of Experimental Atherosclerosis in Mice. JACC Basic Transl Sci, 11(9):101649(2026) [pubmed] |
Keyword List
| submitter keyword: Plasma, Atherosclerosis, DIA, Nanoparticle, Proteomics |
Contact List
| Masanori Aikawa |
|---|
| contact affiliation | Center for Interdisciplinary Cardiovascular Sciences, Department of Medicine, Briham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA |
| contact email | maikawa@bwh.harvard.edu |
| lab head | |
| Sasha Singh |
|---|
| contact affiliation | Brigham and Women's Hospital, Harvard Medical School |
| contact email | sasingh@bwh.harvard.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD063218 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD063218
- Label: PRIDE project
- Name: Nanoparticle-enabled plasma proteomics of a preclinical atherosclerosis model reveals common signatures with human disease
