PXD063205 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Targeted Deletion of EMMPRIN in Microglia/Macrophages Mitigates Neuronal Death in Intracerebral Hemorrhage |
| Description | Intracerebral hemorrhage (ICH) is a devastating subtype of stroke with high mortality and limited therapeutic options. Microglia and macrophages are myeloid cells that are rapidly recruited into ICH lesions where they contribute to secondary brain injury. However, the driver of myeloid cell neurotoxicity remains incompletely understood. Here, we interrogated extracellular matrix metalloproteinase inducer (EMMPRIN, CD147) in promoting microglia/macrophage neurotoxicity in ICH. Using both AAV-mediated knockdown and CX3CR1Cre:EMMPRINfl/fl mice, we demonstrate that EMMPRIN deletion in microglia/macrophages reduced neuronal death and improved functional recovery after ICH. EMMPRIN-mediated neurotoxicity in ICH was associated with elevation of matrix metalloproteinases, and reduced signaling through the p38/MAPK, MEF2C transcription factor and Bcl2 anti-apoptotic pathway. Correspondent with lower injury, EMMPRIN deletion enhanced neurogenesis and oligodendrogenesis in ICH. These findings establish EMMPRIN elevation in myeloid cells as a prominent regulator of ICH pathophysiology and a promising therapeutic target to limit secondary injury and promote brain repair. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-26 |
| AnnouncementXML | Submission_2026-01-25_16:37:18.550.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Daniel Young |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | acetylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-22 16:49:07 | ID requested | |
| ⏵ 1 | 2026-01-25 16:37:19 | announced | |
Publication List
| 10.1186/s13024-025-00917-x; |
| Li Z, Zhang X, Mobarakabadi M, Liu Y, Wei R, Silva C, Visser F, Dufour A, Young D, Kaushik D, Yong VW, Xue M, Targeted deletion of EMMPRIN in microglia/macrophages mitigates neuronal death in intracerebral hemorrhage. Mol Neurodegener, 21(1):4(2025) [pubmed] |
Keyword List
| submitter keyword: Intracerebral hemorrhage |
| EMMPRIN |
| Microglia/macrophages |
| Matrix metalloproteinases |
| Neuroprotection |
| Regeneration |
Contact List
| Antoine Dufour |
|---|
| contact affiliation | Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada Departments of Biochemistry and Molecular Biology, and Physiology and Pharmacology, and McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Canada |
| contact email | Antoine.Dufour@ucalgary.ca |
| lab head | |
| Daniel Young |
|---|
| contact affiliation | University of Calgary |
| contact email | daniel.young1@ucalgary.ca |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD063205 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD063205
- Label: PRIDE project
- Name: Targeted Deletion of EMMPRIN in Microglia/Macrophages Mitigates Neuronal Death in Intracerebral Hemorrhage
