PXD063126 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | DIA-Based Phosphoproteomic Analysis of Kidney Tissues in Mice with Acetaminophen-Induced Kidney Injury |
| Description | Acetaminophen (APAP) overdose can lead to acute kidney injury (AKI), yet its molecular mechanisms remain unclear and no effective treatments are currently available. In this study, we combined transcriptomic, proteomic, and phosphoproteomic profiling of kidneys from APAP-exposed mice to explore molecular mechanisms and potential therapeutic strategies. Ten-week-old male C57BL/6 mice were fasted overnight for 16 hours prior to APAP treatment. Acute kidney injury was induced by intraperitoneal injection of APAP overdose (300 mg/kg body weight) for 6 hours (n = 4). Control mice received an equivalent volume of PBS via intraperitoneal injection (n = 4). Kidney tissues were subsequently collected from APAP-induced kidney injury mice and PBS-injected controls. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-05 |
| AnnouncementXML | Submission_2025-12-05_01:10:07.485.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jianxin Zheng |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | phosphorylated residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-19 09:23:42 | ID requested | |
| ⏵ 1 | 2025-12-05 01:10:08 | announced | |
Publication List
| 10.1080/0886022x.2025.2580064; |
| Zheng J, Lai P, Wu J, Li Y, Chen F, Zhu D, A multi-omics landscape of programmed cell death in acetaminophen-induced acute kidney injury. Ren Fail, 47(1):2580064(2025) [pubmed] |
Keyword List
Contact List
| Jianxin Zheng |
|---|
| contact affiliation | Department of Urology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China |
| contact email | zheng.jianxin@zsxmhospital.com |
| lab head | |
| Jianxin Zheng |
|---|
| contact affiliation | Department of Urology, Zhongshan Hospital (Xiamen), Fudan University |
| contact email | zheng.jianxin@zsxmhospital.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD063126 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD063126
- Label: PRIDE project
- Name: DIA-Based Phosphoproteomic Analysis of Kidney Tissues in Mice with Acetaminophen-Induced Kidney Injury
