PXD062999 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comprehensive Proteome Profiling of Cytochrome P450 Isoforms in Cancer Models |
| Description | Cytochrome P450 (CYP450) enzymes are essential for drug metabolism, xenobiotic detoxification, and procarcinogen activation, playing a pivotal role in both normal physiology and cancer biology. Their expression varies significantly across tissues and tumour types, reflecting the metabolic heterogeneity of cancers. Understanding these variations is critical for developing targeted therapies, optimizing drug efficacy, and minimizing toxicity. This study aimed to comprehensively profile CYP450 expression in colorectal cancer (CRC), head and neck squamous cell carcinoma (HNSCC), breast cancer, and hepatic cancer models. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-10 |
| AnnouncementXML | Submission_2025-11-09_20:33:54.121.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Sadr Shaheed |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-15 14:16:28 | ID requested | |
| ⏵ 1 | 2025-11-09 20:34:01 | announced | |
Publication List
| 10.1186/s12014-025-09565-1; |
| Shaheed SU, Al-Eidan AA, Pors K, Patterson L, Sutton CW, Comprehensive proteome profiling of cytochrome P450 isoforms in cancer models. Clin Proteomics, 22(1):41(2025) [pubmed] |
Keyword List
| submitter keyword: CYP450 enzymes, Personalized therapy, Colorectal Cancer, GEL-LC-MS, Head and neck cancer, Biomarkers |
Contact List
| Sadr ul Shaheed |
|---|
| contact affiliation | Nuffield Department of Surgical Sciences, University of Oxford UK |
| contact email | sadr.shaheed@nds.ox.ac.uk |
| lab head | |
| Sadr Shaheed |
|---|
| contact affiliation | Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom |
| contact email | sadr.shaheed@nds.ox.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD062999 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD062999
- Label: PRIDE project
- Name: Comprehensive Proteome Profiling of Cytochrome P450 Isoforms in Cancer Models
