PXD062988-1

PXD062988 is an original dataset announced via ProteomeXchange.

Title	Proteome analysis of WT, TPC2 knockout and TRPML1 knockout HCC cell lines
Description	Our proteome analysis revealed that TPC2 ablation alters tumor metabolism while we did not observe the same effect in the case of TRPML1 knockout.
HostingRepository	PRIDE
AnnounceDate	2026-03-12
AnnouncementXML	Submission_2026-03-12_09:24:07.243.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jan Bernd Stöckl
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF HT

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-15 08:43:11	ID requested
⏵ 1	2026-03-12 09:24:08	announced

Ouologuem L, K, ü, bler A, Ouologuem S, Hadzic A, St, ö, ckl JB, Siciliano AC, Forciniti S, Nigro S, Iuele H, Onesto V, Nguyen A, Matzek D, Abrahamian C, Grimm C, Popper B, Gigli G, Del Mercato LL, Merkel OM, Fr, ö, hlich T, Theurich S, Bartel K, Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC. Front Immunol, 16():1668066(2025) [pubmed]

10.3389/fimmu.2025.1668066;

submitter keyword: TRPLML1, TPC2, melanoma,hepatocellular carcinoma

Thomas Fröhlich
contact affiliation	Ludwig-Maximilians-Universität München Genzentrum Laboratory for Functional Genome Analysis Feodor-Lynen-Str. 25 D-81377 München
contact email	frohlich@genzentrum.lmu.de
lab head
Jan Bernd Stöckl
contact affiliation	Genzentrum der LMU München
contact email	stoeckl@genzentrum.lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD062988

PRIDE project URI

• PRIDE
  1. PXD062988
     1. Label: PRIDE project
     2. Name: Proteome analysis of WT, TPC2 knockout and TRPML1 knockout HCC cell lines