PXD062953 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Title Heme acts as a molecular degrader linking CRL2-FEM1B to substrate proteolysis and ferroptosis regulation in lung cancer |
| Description | In this project, we attempted to explore the differential proteins profile of lung cancer cells in which the BACH1-CRL2 pathway was manipulated. To this end, we performed DIA-based quantitative proteomics in mouse lung adenocarcinoma KP cells. Control cells and BACH1 null cells were used. Additionally, the expression of CRL2 was silenced using siRNA. A cell line transfected with an siCTRL was used as negative control. 3 biological replicates were used for each sample group. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-11 |
| AnnouncementXML | Submission_2026-06-11_09:06:19.356.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | AUDEBERT Stephane |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-14 16:55:05 | ID requested | |
| ⏵ 1 | 2026-06-11 09:06:20 | announced | |
Publication List
| 10.1016/j.molcel.2026.04.008; |
| Ahmed B, Salaun D, Jordan JB, Daulat A, Pastorello C, Brito T, Yang Y, Josselin E, Byrne D, Betzi S, Pelletier A, Vernerey J, Ferreira L, Castellano R, Audebert S, Camoin L, Pane A, Bechara C, Borg JP, Modesti M, Lignitto L, uses heme to recruit BACH1 for degradation and regulate ferroptosis in lung cancer. Mol Cell, 86(10):1993-2011.e10(2026) [pubmed] |
Keyword List
| submitter keyword: KP |
| BACH1 |
| CRL2 |
| NSCLC |
| LC-MSMS |
| DIA |
Contact List
| Dr Luca Lignitto |
|---|
| contact affiliation | CRCM, INSERM, CNRS, Institut Paoli-Calmettes, Aix-Marseille Univ. , 27 Boulevard Leï Roure, 13009, Marseille, France |
| contact email | luca.lignitto@inserm.fr |
| lab head | |
| AUDEBERT Stephane |
|---|
| contact affiliation | Marseille Proteomic, Centre de Recherche en Cancérologie de Marseille, Inserm UMR1068, CNRS UMR7258, Aix Marseille Université U105, Institut Paoli Calmettes, 27 Boulevard Leï Roure CS30059 13273 Marseille Cedex 09 France |
| contact email | stephane.audebert@inserm.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD062953 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD062953
- Label: PRIDE project
- Name: Title Heme acts as a molecular degrader linking CRL2-FEM1B to substrate proteolysis and ferroptosis regulation in lung cancer
