PXD062951 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A neuropeptide regulates cell non-autonomous protein homeostasis |
| Description | The coordination of protein homeostasis from the brain to periphery is essential for the health and survival of all animals. In C. elegans, glia serve a central role in coordinating organismal protein homeostasis and longevity via the unfolded protein response of the endoplasmic reticulum (UPRER). However, the full extent of the cell non-autonomous response and the identity of the signaling molecules required remained unknown. Here, we show that glial UPRER activation induces robust transcriptomic changes in specific tissue types across the animal, particularly in pathways related to neuropeptide signaling. We performed neuropeptidomics and loss and gain-of-function genetic screens and identified a single neuropeptide, FLP-17, that is sufficient but not necessary to induce cell non-autonomous activation of the UPRER. FLP-17 is sufficient to protect against chronic ER stress and age-dependent protein aggregation. We determined that FLP-17 acts through the receptor, EGL-6, to activate cell non-autonomous UPRER. This work reveals a complex peptidergic signaling network initiated by glial activation of the UPRER to regulate organismal protein homeostasis. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-09 |
| AnnouncementXML | Submission_2026-03-09_04:20:14.032.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD062951 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Jacqueline Lo |
| SpeciesList | scientific name: Caenorhabditis elegans; NCBI TaxID: NEWT:6239; |
| ModificationList | amidated residue; 2-pyrrolidone-5-carboxylic acid (Glu); half cystine; 2-pyrrolidone-5-carboxylic acid (Gln); phosphorylated residue; monohydroxylated residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-14 16:40:57 | ID requested | |
| ⏵ 1 | 2026-03-09 04:20:14 | announced | |
Publication List
Keyword List
| submitter keyword: neuropeptide, C. elegans, UPR, proteostasis |
Contact List
| Ashley E. Frakes |
|---|
| contact affiliation | Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20814, USA. National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA |
| contact email | ashley.frakes@nih.gov |
| lab head | |
| Jacqueline Lo |
|---|
| contact affiliation | Buck Institute for Research on Aging |
| contact email | jlo@buckinstitute.org |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD062951
- Label: PRIDE project
- Name: A neuropeptide regulates cell non-autonomous protein homeostasis
