PXD062940 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Chronic Midazolam Exposure on Neonates and Long-Term Neurodevelopment |
| Description | About 1 in 10 U.S. newborns are born preterm and often require sedation, which may pose long-term neurodevelopmental risks. This study examined the effects of chronic exposure to midazolam (MDZ), a sedative commonly used in NICUs, using a rodent model. Researchers assessed physical, molecular, biochemical, and behavioral outcomes across development. Results showed that early MDZ exposure led to early childhood growth issues, abnormal weight gain patterns in adulthood (suggesting a risk of binge eating), reduced dopamine release, increased brain inflammation markers, and signs of anxiety and social deficits in adolescence. The study highlights potential long-term impacts of neonatal MDZ use on brain and behavior. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-10-27 |
| AnnouncementXML | Submission_2025-10-26_18:06:51.684.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Gurudutt Pendyala |
| SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-14 09:40:59 | ID requested | |
| ⏵ 1 | 2025-10-26 18:06:52 | announced | |
Publication List
| Nguyen NM, Athota P, Flores A, Trease A, Meyer D, Singu VK, Krishnamoorthy C, Schaal VL, Bhakat R, Sualy K, Natarajan SK, Stauch K, Yelamanchili SV, Pendyala G, Comprehensive characterization of chronic midazolam exposure on neonates and long-term neurodevelopment. Mol Psychiatry, 30(11):5203-5214(2025) [pubmed] |
| 10.1038/s41380-025-03104-y; |
Keyword List
| submitter keyword: Midazolam,Neurodevelopment |
Contact List
| Dr. Gurudutt N. Pendyala |
|---|
| contact affiliation | Head of Pendyala Lab Robert Lieberman Endowed Professor of Anesthesiology University of Nebraska Medical Center College of Medicine,Department of Anesthesiology Omaha,Nebraska,United states. |
| contact email | gpendyala@unmc.edu |
| lab head | |
| Gurudutt Pendyala |
|---|
| contact affiliation | University of Nebraska Medical Center |
| contact email | gpendyala@unmc.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD062940 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD062940
- Label: PRIDE project
- Name: Chronic Midazolam Exposure on Neonates and Long-Term Neurodevelopment
