PXD062832-1

PXD062832 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	TNFRSF11B-modified umbilical cord mesenchymal stem cells as a novel strategy for bone-related diseases by suppressing osteoclast activity
Description	This study explored the proteomic changes in UCMSCs cells following TNFRSF11B gene overexpression. Stable overexpression of TNFRSF11B in UCMSCs via lentiviral transduction. Proteomic analysis was conducted on the conditioned medium from control UCMSCs and TNFRSF11B-overexpressing UCMSCs. Transfected cells were seeded in culture flasks, and the culture medium was collected after 2 days and rapidly frozen in -80℃. The differential protein expression profile linked to TNFRSF11B overexpression in UCMSCs was analyzed using 4D label-free proteomics (PTM Bio, Hangzhou).
HostingRepository	PRIDE
AnnounceDate	2025-05-21
AnnouncementXML	Submission_2025-05-20_19:46:49.662.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mina Ding
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-10 21:37:29	ID requested
⏵ 1	2025-05-20 19:46:50	announced

Publication List

10.1186/S13018-025-05850-9;

10.1186/S13018-025-05850-9;

Keyword List

submitter keyword: Bone remodeling
TNFRSF11B
UCMSCs
Osteoclast differentiation
Proteomics

submitter keyword: Bone remodeling

TNFRSF11B

UCMSCs

Osteoclast differentiation

Proteomics

Contact List

Jian V. Zhang
contact affiliation	Shenzhen Key Laboratory of Metabolic Health，Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology，Chinese Academy of Sciences
contact email	jian.zhang@siat.ac.cn
lab head
Mina Ding
contact affiliation	Shenzhen Beike Biotechnology Co., Ltd
contact email	dingmina@beike.cc
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD062832
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD062832

PRIDE project URI

Repository Record List

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