PXD062823-1

PXD062823 is an original dataset announced via ProteomeXchange.

Title	Spinal cord phosphoproteome of SCA2/ALS13 mouse model
Description	Toxic polyglutamine (polyQ) expansions in ATXN2 trigger neurodegenerative processes, causing Spinocerebellar Ataxia type 2 (SCA2), and enhancing TDP 43-dependent pathology in Amyotrophic Lateral Sclerosis (ALS) / Fronto-Temporal Dementia (FTD). Primary disease events can be compensated transiently, delaying disease manifestation. To define potential therapy targets, we documented how cells modify their phospho-signals and how the ATXN2 interactome changes, using preferentially affected nervous tissues from end-stage Atxn2-CAG100-KnockIn mice.
HostingRepository	PRIDE
AnnounceDate	2025-09-29
AnnouncementXML	Submission_2025-09-29_01:13:29.890.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jana Key
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	formylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-10 13:06:42	ID requested
⏵ 1	2025-09-29 01:13:30	announced

Almaguer-Mederos LE, Kandi AR, Sen NE, Canet-Pons J, Berger LM, Stokes MP, Abell K, Key J, Gispert S, Auburger G, Spinal Cord Phosphoproteome of SCA2 Mouse Model Reveals Alteration of ATXN2-N-Term PRM-SH3-Actin Interactome and of Autophagy. Mol Cell Proteomics, 24(11):101072(2025) [pubmed]

10.1016/j.mcpro.2025.101072;

submitter keyword: Fe-NTA binding

IMAC

cortico-spinal motoneurons

cerebellar Purkinje neurons

tyrosine receptor endocytosis

intrinsically disordered domains

liquid-liquid phase separation

proteasome

aggrephagy

microtubule-organizing center.

Georg Auburger
contact affiliation	Experimental Neurology, University Hospital, Frankfurt am Main, Germany
contact email	auburger@em.uni-frankfurt.de
lab head
Jana Key
contact affiliation	University Hospital Frankfurt am Main
contact email	jana.key88@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD062823

PRIDE project URI

• PRIDE
  1. PXD062823
     1. Label: PRIDE project
     2. Name: Spinal cord phosphoproteome of SCA2/ALS13 mouse model