PXD062815-1

PXD062815 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Unveiling novel histotype-specific biomarkers in ovarian carcinoma using proteomics
Description	Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy, yet clinical tools for diagnosis, prognosis and treatment remain limited, and molecular profiling of histotypes is lacking. Here, we leverage proteomic data to further stratify four main EOC histotypes, borderline, and benign tumors and identify novel prognostic and diagnostic biomarkers. Using proteomic data from 300 patient samples, we identified differentially abundant proteins (DAPs) such as SNCG, S100A1, VWA2, AGR2, CTH, and SPINK1 and biomarker panels to stratify the tissues. Enrichment of biological processes profiled histotypes and involvement of DAPs. Survival analysis identified candidate biomarkers predicting overall- and disease-specific survival with histotype-specificity. Of these, GLYR1, RPL12, GDPGP1, and POLR2M were associated with favorable outcomes, while SDF4, PPP3CC, EIF2AK2, and STX6 were linked to unfavorable outcomes. Collectively, these findings provide attributes spefici for histotypes for known and novel EOC biomarkers that may serve as new clinical tools for EOC treatment decisions and diagnosis.
HostingRepository	MassIVE
AnnounceDate	2025-08-10
AnnouncementXML	Submission_2025-08-10_22:44:09.974.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lucas Werner
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Oxidation; Acetyl; Carbamidomethyl
Instrument	timsTOF HT

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-10 10:12:28	ID requested
⏵ 1	2025-08-10 22:44:10	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: epithelial ovarian cancer, histotype, ovarian borderline, ovarian benign, proteomics, disease stratification, differential abundance analysis, biomarkers, biomarker panels, enrichment analysis, survival analysis, fresh-frozen tissue, novel biomarkers, biomarker discovery, DatasetType:Proteomics

submitter keyword: epithelial ovarian cancer, histotype, ovarian borderline, ovarian benign, proteomics, disease stratification, differential abundance analysis, biomarkers, biomarker panels, enrichment analysis, survival analysis, fresh-frozen tissue, novel biomarkers, biomarker discovery, DatasetType:Proteomics

Contact List

Khalil Helou
contact affiliation	University of Gothenburg, Institute of Clinical Sciences, Department of Oncology
contact email	khalil.helou@oncology.gu.se
lab head
Lucas Werner
contact affiliation	University of Gothenburg
contact email	lucas.werner@gu.se
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v09/MSV000097588/