PXD062776 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | TCA rewiring underpins implantation and acetylome programming |
| Description | Metabolism has emerged as a crucial regulator of development and stem cell epigenome. This coupling is particularly evident during the in vitro exit from naïve pluripotency. However, our understanding of the dynamic metabolic rewiring at this developmental stage remains rudimentary. In this study, we reconstruct intracellular metabolite routings in pre- and post-implantation mouse embryos and their dynamic stem cell models. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-08 |
| AnnouncementXML | Submission_2026-06-07_17:16:25.812.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Roberta Noberini |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | monomethylated residue; N6; acetylated residue; dimethylated residue |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-09 01:28:43 | ID requested | |
| ⏵ 1 | 2026-06-07 17:16:26 | announced | |
Publication List
| 10.1016/j.stem.2026.04.004; |
| Kafkia E, Pladevall-Morera D, Argemi-Muntadas L, Wang G, Noberini R, Cas, ò, liba-Melich A, Bag, é, s-Arnal S, Anagho-Mattanovich M, Silv, é, rio-Alves R, Gassler J, Bonaldi T, Rabelink TJ, Moritz T, Ż, ylicz JJ, TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency. Cell Stem Cell, 33(5):820-836.e9(2026) [pubmed] |
Keyword List
| submitter keyword: metabolism, development,histone post translational modifications |
Contact List
| Tiziana Bonaldi |
|---|
| contact affiliation | European Institute of Oncology, Milan, Italy |
| contact email | tiziana.bonaldi@ieo.it |
| lab head | |
| Roberta Noberini |
|---|
| contact affiliation | Istituto Europeo di Oncologia |
| contact email | roberta.noberini@ieo.it |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD062776 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD062776
- Label: PRIDE project
- Name: TCA rewiring underpins implantation and acetylome programming
