PXD062745-1

PXD062745 is an original dataset announced via ProteomeXchange.

Title	The source of dietary fat influences the immune response to syngeneic tumours in obesity – NK cell proteomic data
Description	Obesity is linked to an increased risk of many cancers and can impair the anti-tumour immune response. This project examined the effect of different sources of dietary fats on tumour immunity using a syngeneic model of melanoma in mice fed high fat diets (HFD) derived from different sources. HFD based on beef tallow, lard and butter increased tumour growth in this model, while HFD derived from coconut oil, palm oil or olive oil did not. Further experiments focusing on butter and palm oil based HFD found differential regulation of natural killer (NK) cells and CD8 T-cell infiltration and function in the tumour microenvironment, and identified enrichment in immunosuppressive long chain acylcarnitine species in mice fed a HFD based on butter compared to palm oil. This dataset contains proteomic data from NK cells from mice fed a standard fat diet (SFD), NK cells from mice fed a HFD based on butter and from mice fed a HFD based on palm oil.
HostingRepository	PRIDE
AnnounceDate	2025-06-03
AnnouncementXML	Submission_2025-06-03_08:31:27.778.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christina Rollings
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-08 10:16:28	ID requested
⏵ 1	2025-06-03 08:31:28	announced

Dataset with its publication pending

submitter keyword: metabolism,NK cells, diet, anti-tumour immunity

Lydia Lynch
contact affiliation	Department of Molecular Biology, Princeton University, US
contact email	ll6483@princeton.edu
lab head
Christina Rollings
contact affiliation	University of Dundee
contact email	crollings@dundee.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD062745

PRIDE project URI

• PRIDE
  1. PXD062745
     1. Label: PRIDE project
     2. Name: The source of dietary fat influences the immune response to syngeneic tumours in obesity – NK cell proteomic data