⮝ Full datasets listing
PXD062744-1
PXD062744 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Titin cleavage impairs cardiac mechanical connectivity to drive diastolic failure and fibrosis |
| Description | A mouse model of titin cleavage in which a tobacco etch virus (TEV) protease recognition site is inserted into the I-band region of titin between Ig domains 86 and 87 was used. Myocardial-specific cleavage was induced via AAV9-mediated TEV expression under a cardiac troponin T (cTnT) promoter, delivered by tail-vein injections into homozygous (Hom) or heterozygous (Het) TC mice, with AAV9-GFP serving as a control. Hearts from these mice were collected 6 and 13 days after AAV9 delivery. Lysates from these heart samples were reduced, alkylated, trypsin digested and desalted. Results files were generated using ProteomeDiscoverer2.5. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-05-05 |
| AnnouncementXML | Submission_2026-05-05_15:46:20.521.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Michaela Door |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Acetyl |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-04-08 10:02:15 | ID requested | |
| ⏵ 1 | 2026-05-05 15:46:21 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: titin, titin cleavage, diastolic failure, cardiomyocyte, fibrosis, DatasetType:Proteomics |
Contact List
| Wolfgang Linke | |
|---|---|
| contact affiliation | University of Muenster |
| contact email | wlinke@uni-muenster.de |
| lab head | |
| Jonathan Kirk | |
| contact affiliation | Loyola University Chicago |
| contact email | jkirk2@luc.edu |
| lab head | |
| Michaela Door | |
| contact affiliation | Loyola University Chicago |
| contact email | mdoor@luc.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v09/MSV000097567/ |
